NFL Week 6: Sunday, Game by Game

Twelve games start with Texans at Jaguars in London at 9:30 AM ET and end with Cowboys at Packers on NBC at 8:20 PM. Quarterbacks are missing in Baltimore, Philadelphia, and Tampa Bay, so read the injury lines before you read the leans, because the leans were made around them.

Texans at Jaguars

9:30 AM ET, London, Wembley Stadium | NFL Network | Jaguars -2.5 | Total 42.5 | DraftKings

Injuries: Houston: Tank Dell (knee), David Montgomery (groin), and Jalen Pitre (shoulder) are out; Jacksonville listed no offensive skill player.

Nico Collins (WR, Texans): play him

Collins has 19 catches on 25 targets for 249 yards and 3 touchdowns in 3 games, and the Jaguars are down Montaric Brown with Jaylon Jones questionable at corner. Easy.

Parker Washington (WR, Jaguars): play him

Washington has 22 catches on 35 targets for 352 yards and 4 touchdowns, a target share that earns him WR2 treatment no matter how little his name excites you.

Woody Marks (RB, Texans): flex

Marks has 43 carries for 149 yards and 2 touchdowns plus 11 catches for 54 yards, and with Montgomery out he gets the work. Jacksonville is a miserable matchup for running backs, so treat him as a flex, not a centerpiece.

Bears at Falcons

1:00 PM ET | FOX | Bears -1 | Total 52.5 | Bovada

Injuries: Caleb Williams is questionable (hamstring) and Kyle Monangai is out for Chicago; Atlanta listed no offensive skill player.

Bijan Robinson (RB, Falcons): play him

Robinson has 102 carries for 580 yards and 4 rushing touchdowns, and the Chicago front is short T.J. Edwards, Keyshaun Elliott, and Dayo Odeyingbo with Montez Sweat suspended.

D'Andre Swift (RB, Bears): play him

With Monangai out, Swift is the lead back with 78 carries for 354 yards and 4 touchdowns, plus 14 catches for 114 yards.

Drake London (WR, Falcons): play him

London has 27 catches on 37 targets for 488 yards and no touchdowns yet. Michael Penix Jr. practiced fully, and Kyler Gordon and Tyrique Stevenson are questionable at corner for Chicago.

Ravens at Browns

1:00 PM ET | FOX | Ravens -3 | Total 39.5 | DraftKings

Injuries: Lamar Jackson is out (ankle) and Ja'Kobi Lane is questionable (wrist) for Baltimore; Quinshon Judkins is questionable (ankle) and Dylan Sampson is out (knee) for Cleveland.

Derrick Henry (RB, Ravens): play him

Henry has 113 carries for 476 yards and 7 rushing touchdowns, and with Tyler Huntley replacing Jackson the Ravens have every reason to hand him the ball until his arms fall off.

Zay Flowers (WR, Ravens): play him

Flowers has 26 catches on 31 targets for 405 yards and 2 touchdowns. Lower your ceiling with Huntley throwing and a 39.5 total, but that target share holds.

Quinshon Judkins (RB, Browns): sit him

Judkins is questionable with an ankle injury and has 73 carries for 221 yards and 1 touchdown. That is 3.0 yards a carry in a game with a 39.5 total, and you do not need to be the one finding out how it ends.

Titans at Colts

1:00 PM ET | FOX | Colts -7 | Total 44.5 | DraftKings

Injuries: Tyjae Spears is questionable (knee) for Tennessee; Ashton Dulin is out (hamstring) and Tyler Warren is questionable (groin) for Indianapolis.

Jonathan Taylor (RB, Colts): play him

Taylor has 101 carries for 398 yards and 6 rushing touchdowns, plus 13 catches for 106 yards, and Indianapolis is a 7-point favorite.

Tony Pollard (RB, Titans): flex

Pollard has 68 carries for 273 yards and 1 touchdown, a steady workload with Spears questionable. Playable, but the game script against a 7-point favorite caps it.

Jets at Patriots

1:00 PM ET | CBS | Patriots -7.5 | Total 43.5 | DraftKings

Injuries: Breece Hall (quad) and Adonai Mitchell (finger) are out for the Jets, with Omar Cooper Jr. and Kenyon Sadiq questionable; A.J. Brown and TreVeyon Henderson are questionable for New England.

Braelon Allen (RB, Jets): play him

With Hall out, Allen has 57 carries for 236 yards and 2 touchdowns, including 24 carries for 116 yards last game. He is the volume back.

Garrett Wilson (WR, Jets): play him

Wilson has 31 catches for 374 yards and 3 touchdowns, and Mitchell's absence leaves him as the focal point of the passing game.

Rhamondre Stevenson (RB, Patriots): flex

Stevenson has 57 carries for 227 yards and 2 touchdowns plus 15 catches for 111 yards, with Henderson questionable and New England favored by 7.5.

Saints at Giants

1:00 PM ET | FOX | Saints -1.5 | Total 46.5 | DraftKings

Injuries: Alvin Kamara (back) and Chris Olave (illness) are questionable for New Orleans; Theo Johnson is out (neck) for the Giants.

Chris Olave (WR, Saints): play him

Olave has 39 catches on 54 targets for 537 yards and 1 touchdown. The illness tag is the only risk, so check he is active before you lock it in.

Malik Nabers (WR, Giants): play him

Nabers has 29 catches on 46 targets for 329 yards and 2 touchdowns, and Saints cornerback Kool-Aid McKinstry has allowed 255 coverage yards.

Cam Skattebo (RB, Giants): play him

Skattebo has 81 carries for 294 yards and 1 touchdown, and New Orleans has allowed a league-high 133.4 rushing yards per game to running backs.

Panthers at Eagles

1:00 PM ET | CBS | Panthers -3 | Total 39.5 | DraftKings

Injuries: Jalen Hurts (calf), Saquon Barkley (hamstring), and Will Shipley (foot) are out for Philadelphia, with Grant Calcaterra and Eli Stowers questionable; A.J. Dillon is out (ankle) and Trevor Etienne questionable (ankle) for Carolina.

Chuba Hubbard (RB, Panthers): play him

Hubbard has 61 carries for 306 yards and 3 rushing touchdowns plus 10 catches for 84 yards and 2 more scores, and the backfield behind him is thin with Dillon out.

Tetairoa McMillan (WR, Panthers): play him

McMillan has 26 catches on 39 targets for 385 yards and still no touchdown, which is a volume line waiting for the touchdown regression to show up.

DeVonta Smith (WR, Eagles): flex

Smith has 19 catches on 27 targets for 235 yards and 1 touchdown, but Tanner McKee is replacing Hurts, which lowers the ceiling.

Steelers at Buccaneers

1:00 PM ET | CBS | Steelers -2.5 | Total 38.5 | DraftKings

Injuries: Baker Mayfield (thumb) is out and Sean Tucker is questionable (quad) for Tampa Bay; Rico Dowdle (toe) and DK Metcalf (illness) were both questionable on Friday's report for Pittsburgh, so check inactives.

Jaylen Warren (RB, Steelers): play him

Warren has 70 carries for 410 yards and 19 catches for 230 yards, with a score each way, and the floor is real even against a stingy Tampa run defense.

Bucky Irving (RB, Buccaneers): play him

Irving has 77 carries for 406 yards and 2 touchdowns plus 15 catches for 71 yards, and with Mayfield out the offense should lean on its lead back.

DK Metcalf (WR, Steelers): flex

Metcalf has 19 catches on 37 targets for 225 yards and 1 touchdown, and he was questionable with an illness Friday. A flex play, because 19 catches on 37 targets is not a lock.

Cardinals at Rams

4:05 PM ET | FOX | Rams -12.5 | Total 51.5 | BetMGM

Injuries: Jeremiyah Love is out (ankle) for Arizona; the Rams listed no offensive skill player.

Puka Nacua (WR, Rams): play him

Nacua has 31 catches on 45 targets for 337 yards and 1 touchdown in 3 games, against an Arizona secondary missing Wydett Williams Jr. and Andrew Wingard.

Kyren Williams (RB, Rams): play him

Williams has 70 carries for 343 yards and 4 rushing touchdowns plus 27 catches for 200 yards, and the Rams are 12.5-point favorites.

Trey McBride (TE, Cardinals): play him

McBride has 42 catches on 56 targets for 308 yards and 3 touchdowns, and Arizona with no Love is likely to be chasing the Rams all afternoon.

Chargers at Chiefs

4:25 PM ET | CBS | Chiefs -7.5 | Total 41.5 | DraftKings

Injuries: Tre' Harris (hamstring) and tackle Joe Alt (neck) are out for the Chargers; Rashee Rice is out (hamstring/knee) for the Chiefs.

Kenneth Walker III (RB, Chiefs): play him

Walker has 87 carries for 537 yards and 4 rushing touchdowns, plus 12 catches for 84 yards and 2 more scores, and the Chargers are missing Joe Alt and Derwin James Jr.

Travis Kelce (TE, Chiefs): play him

Kelce has 16 catches on 22 targets for 246 yards and 2 touchdowns, and Rashee Rice being out sends targets his way.

Justin Herbert (QB, Chargers): sit him

Herbert is 85 of 143 for 937 yards, 5 touchdowns, and 7 interceptions, and he is playing without Joe Alt against a Kansas City defense allowing 19.3 points a game, seventh of 32.

Bills at Raiders

4:25 PM ET | CBS | Bills -5.5 | Total 53.5 | FanDuel

Injuries: DJ Moore and Joshua Palmer are questionable (shoulder) for Buffalo; Dont'e Thornton Jr. is out (hamstring) for Las Vegas, while Brock Bowers and Ashton Jeanty carry no designation.

Josh Allen (QB, Bills): play him

Allen has thrown for 1,249 yards and 7 touchdowns and run for 239 yards and 8 more, against a Raiders defense that allowed 4 passing touchdowns last week.

James Cook (RB, Bills): play him

Cook has 95 carries for 532 yards and 5 touchdowns, and Las Vegas has allowed 5.2 yards per carry.

Ashton Jeanty (RB, Raiders): flex

Jeanty has 88 carries for 291 yards and 22 catches on 30 targets for 215 yards and 2 touchdowns, and Buffalo ranks 28th in running back fantasy points allowed.

Cowboys at Packers

8:20 PM ET | NBC | Packers -1.5 | Total 53.5 | DraftKings

Injuries: Skyy Moore is out (ankle) and Savion Williams questionable (ankle) for Green Bay; Dallas listed no offensive skill player, and CeeDee Lamb (thigh) practiced fully.

CeeDee Lamb (WR, Cowboys): play him

Lamb has 39 catches on 51 targets for 507 yards and 4 touchdowns, with no game designation after a thigh injury.

Javonte Williams (RB, Cowboys): play him

Williams has 74 carries for 276 yards and 6 rushing touchdowns, and Green Bay has allowed 638 rushing yards and 8 rushing touchdowns.

Christian Watson (WR, Packers): play him

Watson has 26 catches on 40 targets for 474 yards and 6 touchdowns, which is downfield, touchdown-heavy usage, and Skyy Moore being out only thins the competition.

Lines are as of Saturday afternoon and can move before kickoff; check inactives about 90 minutes before your games lock. That's the slate, and the stat lines above run through Week 5.